James S. Harrop, MD

Co-Associate Director for Acute Care,
Regional Spinal Cord Injury Center of the Delaware Valley
Thomas Jefferson University Hospital


Journal Articles

  1. Aarabi B, Harrop JS, Tator CH, Alexander M, Dettori JR, Grossman RG et al. Predictors of pulmonary complications in blunt traumatic spinal cord injury. J Neurosurg Spine 2012; 17(1 Suppl):38-45.
  2. Ahuja CS, Nori S, Tetreault L, Wilson J, Kwon B, Harrop J et al. Traumatic spinal cord injury-repair and regeneration. Neurosurgery 2017; 80(Suppl 3):S9-S22.
  3. Anand N, Vaccaro AR, Lim MR, Lee JY, Arnold P, Harrop JS et al. Evolution of thoracolumbar trauma classification systems: assessing the conflict between mechanism and morphology of injury. Top Spinal Cord Inj Rehabil 2006; 12(1):70-78.
  4. Anderson DG, Sayadipour A, Limthongkul W, Martin ND, Vaccaro A, Harrop JS. Traumatic central cord syndrome: neurologic recovery after surgical management. Am J Orthop 2012; 41(8):E104-E108.
  5. Anderson KK, Tetreault L, Shamji MF, Singh A, Vukas RR, Harrop JS et al. Optimal timing of surgical decompression for acute traumatic central cord syndrome: a systematic review of the literature. Neurosurgery 2015; 77(Suppl 4):S15-S32.
  6. Bagan B, Patel N, Deutsch H, Harrop J, Sharan A, Vaccaro AR et al. Perioperative Complications of Minimally Invasive Surgery (MIS): Comparison of MIS and Open Interbody Fusion Techniques. Surg Technol Int 2008; 17:281-286.
  7. Bono CM, Vaccaro AR, Fehlings M, Fisher C, Dvorak M, Harrop J et al. Measurement techniques for lower cervical spine injuries: consensus statement of the Spine Trauma Study Group. Spine 2006; 31(5):603-609.
  8. Bono CM, Vaccaro AR, Fehlings M, Fisher C, Dvorak M, Harrop J et al. Measurement techniques for upper cervical spine injuries: consensus statement of the Spine Trauma Study Group. Spine 2007; 32(5):593-600.
  9. Chow DS, Teng Y, Toups EG, Aarabi B, Harrop JS, Shaffrey CI et al. Pharmacology of riluzole in acute spinal cord injury. J Neurosurg Spine 2012; 17(1 Suppl):129-140.
  10. Coe JD, Vaccaro AR, Dailey AT, Sasso RC, Ludwig SC, Harrop JS et al. Lateral mass screw fixation in the cervical spine. J Neurosurg Spine 2014; 20(5):592-596.
  11. Coseo NM, Saldua N, Harrop J. Current use of biologic graft extenders for spinal fusion. J Neurosurg Sci 2012; 56(3):203-207.
  12. Fassett DR, Harrop JS, Maltenfort M, Jeyamohan SB, Ratliff JD, Anderson DG et al. Mortality rates in geriatric patients with spinal cord injuries. J Neurosurg Spine 2007; 7(3):277-281.
  13. Fassett DR, Harrop JS, Vaccaro AR. Evidence on magnetic resonance imaging of Brown-Sequard spinal cord injury suffered indirectly from a gunshot wound. J Neurosurg Spine 2008; 8(3):286-287.
  14. Fehlings MG, Furlan JC, Massicotte EM, Arnold P, Aarabi B, Harrop J et al. Interobserver and intraobserver reliability of maximum canal compromise and spinal cord compression for evaluation of acute traumatic cervical spinal cord injury. Spine 2006; 31(15):1719-1725.
  15. Fehlings MG, Theodore N, Harrop J, Maurais G, Kuntz C, Shaffrey CI et al. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma 2011; 28(5):787-796.
  16. Fehlings MG, Vaccaro A, Wilson JR, Singh A, Cadotte W, Harrop JS et al. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One 2012; 7(2):e32037.
  17. Fehlings MG, Wilson JR, Frankowski RF, Toups EG, Aarabi B, Harrop JS et al. Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial. J Neurosurg Spine 2012; 17(1 Suppl):151-156.
  18. Ghobrial GM, Dalyai R, Flanders AE, Harrop J. Nitrous oxide myelopathy posing as spinal cord injury. J Neurosurg Spine 2012; 16(5):489-491.
  19. Ghobrial GM, Amenta PS, Maltenfort M, Williams KA, Jr., Harrop JS, Sharan A et al. Longitudinal incidence and concurrence rates for traumatic brain injury and spine injury - a twenty year analysis. Clin Neurol Neurosurg 2014; 123:174-180.
  20. Ghobrial GM, Maulucci CM, Maltenfort M, Dalyai RT, Vaccaro AR, Fehlings MG et al. Operative and nonoperative adverse events in the management of traumatic fractures of the thoracolumbar spine: a systematic review. Neurosurg Focus 2014; 37(1):E8.
  21. Glennie RA, Ailon T, Yang K, Batke J, Fisher CG, Dvorak MF et al. Incidence, impact, and risk factors of adverse events in thoracic and lumbar spine fractures: an ambispective cohort analysis of 390 patients. Spine J 2015; 15(4):629-637.
  22. Grauer JN, Shafi B, Hilibrand AS, Harrop JS, Kwon BK, Beiner JM et al. Proposal of a modified, treatment-oriented classification of odontoid fractures. Spine J 2005; 5(2):123-129.
  23. Grauer JN, Vaccaro AR, Beiner JM, Kwon BK, Hilibrand AS, Harrop JS et al. Similarities and differences in the treatment of spine trauma between surgical specialties and location of practice. Spine 2004; 29(6):685-696.
  24. Grossman RG, Frankowski RF, Burau KD, Toups EG, Crommett JW, Johnson MM et al. Incidence and severity of acute complications after spinal cord injury. J Neurosurg Spine 2012; 17(1 Suppl):119-128.
  25. Grossman RG, Fehlings MG, Frankowski RF, Burau KD, Chow DS, Tator C et al. A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury. J Neurotrauma 2014; 31(3):239-255.
  26. Gruskay J, Smith J, Kepler CK, Radcliff K, Harrop J, Albert T et al. The seasonality of postoperative infection in spine surgery. J Neurosurg Spine 2013; 18(1):57-62.
  27. Guest J, Harrop JS, Aarabi B, Grossman RG, Fawcett JW, Fehlings MG et al. Optimization of the decision-making process for the selection of therapeutics to undergo clinical testing for spinal cord injury in the North American Clinical Trials Network. J Neurosurg Spine 2012; 17(1 Suppl):94-101.
  28. Harrop JS, Vaccaro A, Przybylski GJ. Acute respiratory compromise associated with flexed cervical traction after C2 fractures. Spine 2001; 26(4):E50-E54.
  29. Harrop JS, Sharan AD, Vaccaro AR, Przybylski GJ. The cause of neurologic deterioration after acute cervical spinal cord injury. Spine 2001; 26(4):340-346.
  30. Harrop JS, Silva MT, Sharan AD, Dante SJ, Simeone FA. Cervicothoracic radiculopathy treated using posterior cervical foraminotomy/discectomy. J Neurosurg 2003; 98(2 Suppl):131-136.
  31. Harrop JS, Hunt GE, Jr., Vaccaro AR. Conus medullaris and cauda equina syndrome as a result of traumatic injuries: management principles. Neurosurg Focus 2004; 16(6):e4.
  32. Harrop JS, Poulsen DJ, Xiao W, Freese A, During MJ. Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytes. Spine 2004; 29(24):2787-2792.
  33. Harrop JS, Sharan AD, Scheid EH, Jr., Vaccaro AR, Przybylski GJ. Tracheostomy placement in patients with complete cervical spinal cord injuries: American Spinal Injury Association Grade A. J Neurosurg 2004; 100(1 Suppl):20-23.
  34. Harrop JS, Sharan A, Anderson G, Hillibrand AS, Albert TJ, Flanders A et al. Failure of standard imaging to detect a cervical fracture in a patient with ankylosing spondylitis. Spine 2005; 30(14):E417-E419.
  35. Harrop JS, Vaccaro AR, Hurlbert RJ, Wilsey JT, Baron EM, Shaffrey CI et al. Intrarater and interrater reliability and validity in the assessment of the mechanism of injury and integrity of the posterior ligamentous complex: a novel injury severity scoring system for thoracolumbar injuries. J Neurosurg Spine 2006; 4(2):118-122.
  36. Harrop JS, Hanna A, Silva MT, Sharan A. Neurological manifestations of cervical spondylosis: an overview of signs, symptoms, and pathophysiology. Neurosurgery 2007; 60(1 Supp1 1):S14-S20.
  37. Harrop JS, Youssef JA, Maltenfort M, Vorwald P, Jabbour P, Bono CM et al. Lumbar adjacent segment degeneration and disease after arthrodesis and total disc arthroplasty. Spine 2008; 33(15):1701-1707.
  38. Harrop JS, Naroji S, Maltenfort MG, Ratliff JK, Tjoumakaris SI, Frank B et al. Neurologic improvement after thoracic, thoracolumbar, and lumbar spinal cord (conus medullaris) injuries. Spine 2011; 36(1):21-25.
  39. Harrop JS, Hashimoto R, Norvell D, Raich A, Aarabi B, Grossman RG et al. Evaluation of clinical experience using cell-based therapies in patients with spinal cord injury: a systematic review. J Neurosurg Spine 2012; 17(1 Suppl):230-246.
  40. Harrop JS, Ghobrial GM, Chitale R, Krespan K, Odorizzi L, Fried T et al. Evaluating initial spine trauma response: Injury time to trauma center in PA, USA. J Clin Neurosci 2014; 21(10):1725-1729.
  41. Harrop JS. Spinal cord injury: debating the efficacy of methylprednisolone. Neurosurgery 2014; 61(1 Suppl):30-31.
  42. Kepler CK, Vaccaro AR, Dibra F, Anderson DG, Rihn JA, Hilibrand AS et al. Neurologic injury because of trauma after type II odontoid nonunion. Spine J 2014; 14(6):903-908.
  43. Lee JY, Vaccaro AR, Lim MR, Oner FC, Hulbert RJ, Harrop J et al. Thoracolumbar injury classification and severity score: a new paradigm for the treatment of thoracolumbar spine trauma. J Orthop Sci 2005; 10(6):671-675.
  44. Nassr A, Lee JY, Dvorak MF, Harrop JS, Dailey AT, Shaffrey CI et al. Variations in surgical treatment of cervical facet dislocations. Spine 2008; 33(7):E188-E193.
  45. Oppenlander ME, Maulucci CM, Ghobrial GM, Harrop JS. Research in spinal surgery: Evaluation and practice of evidence-based medicine. World J Orthop 2014; 5(2):89-93.
  46. Patel AA, Vaccaro AR, Albert TJ, Hilibrand AS, Harrop JS, Anderson DG et al. The adoption of a new classification system: time-dependent variation in interobserver reliability of the thoracolumbar injury severity score classification system. Spine 2007; 32(3):E105-E110.
  47. Patel AA, Vaccaro AR, Martyak GG, Harrop JS, Albert TJ, Ludwig SC et al. Neurologic deficit following percutaneous vertebral stabilization. Spine 2007; 32(16):1728-1734.
  48. Radcliff KE, Kepler CK, Delasotta LA, Rihn JA, Harrop JS, Hilibrand AS et al. Current management review of thoracolumbar cord syndromes. Spine J 2011; 11(9):884-892.
  49. Radcliff K, Su BW, Kepler CK, Rubin T, Shimer AL, Rihn JA et al. Correlation of posterior ligamentous complex injury and neurological injury to loss of vertebral body height, kyphosis, and canal compromise. Spine 2012; 37(13):1142-1150.
  50. Rampersaud RY, Fehlings MG, Harrop JS, Kuklo TR, Massicotte EM, Salonen D et al. Validation of digital radiology measurement tools for quantitative spinal imaging. Top Spinal Cord Inj Rehabil 2006; 12(1):11-21.
  51. Sanfilippo JA, Winegar CD, Harrop JS, Albert TJ, Vaccaro AR. All-terrain vehicles and associated spinal injuries. Spine 2008; 33(18):1982-1985.
  52. Senders ZJ, Zussman BM, Maltenfort MG, Sharan AD, Ratliff JK, Harrop JS. The incidence of pulmonary embolism (PE) after spinal fusions. Clin Neurol Neurosurg 2012; 114(7):897-901.
  53. Smith HE, Rynning RE, Okafor C, Zaslavsky J, Tracy JI, Harrop J et al. Evaluation of neurologic deficit without apparent cause: the importance of a multidisciplinary approach. J Spinal Cord Med 2007; 30(5):509-517.
  54. Smith HE, Maltenfort M, Harrop JS, Bessey JT, Hong J, Yang N et al. Odontoid fractures and their management. Top Spinal Cord Inj Rehabil 2010; 15(3):65-72.
  55. Stricsek G, Ghobrial G, Wilson J, Theofanis T, Harrop JS. Complications in the management of patients with spine trauma. Neurosurg Clin N Am 2017; 28(1):147-155.
  56. Tator CH, Hashimoto R, Raich A, Norvell D, Fehlings MG, Harrop JS et al. Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury. J Neurosurg Spine 2012; 17(1 Suppl):157-229.
  57. Torina PJ, Flanders AE, Carrino JA, Burns AS, Friedman DP, Harrop JS et al. Incidence of vertebral artery thrombosis in cervical spine trauma: correlation with severity of spinal cord injury. Am J Neuroradiol 2005; 26(10):2645-2651.
  58. Vaccaro AR, Harrop JS, Daffner SD, Berta SC. Acute cervical spine injuries in the athlete: diagnosis, management, and return-to-play. International SportMed Journal 2003; 4(1):1-5.
  59. Vaccaro AR, Lehman RA, Jr., Hurlbert RJ, Anderson PA, Harris M, Harrop J et al. A new classification of thoracolumbar injuries: the importance of injury morphology, the integrity of the posterior ligamentous complex, and neurologic status. Spine 2005; 30(20):2325-2333.
  60. Vaccaro AR, Zeiller SC, Hulbert RJ, Anderson PA, Harris M, Harrop J et al. The thoracolumbar injury severity score: a proposed treatment algorithm. J Spinal Disord Tech 2005; 18(3):209-215.
  61. Vaccaro AR, Baron EM, Sanfilippo J, Jacoby S, Steuve J, Harrop J et al. Reliability of a novel classification system for thoracolumbar injuries: the Thoracolumbar Injury Severity Score. Spine 2006; 31(11 Suppl):S62-S69.
  62. Vaccaro AR, Lim MR, Hurlbert RJ, Lehman RA, Jr., Harrop J, Harrop J et al. Surgical decision making for unstable thoracolumbar spine injuries: results of a consensus panel review by the spine trauma study group. J Spinal Disord Tech 2006; 19(1):1-10.
  63. Whang PG, Vaccaro AR, Poelstra KA, Patel AA, Anderson DG, Harrop JS et al. The influence of fracture mechanism and morphology on the reliability and validity of two novel thoracolumbar injury classification systems. Spine 2007; 32(7):791-795.
  64. Wilson JR, Grossman RG, Frankowski RF, Kiss A, Davis AM, Kulkarni AV et al. A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors. J Neurotrauma 2012; 29(13):2263-2271.
  65. Wilson JR, Vaccaro A, Harrop JS, Aarabi B, Shaffrey C, Dvorak M et al. The impact of facet dislocation on clinical outcomes after cervical spinal cord injury: results of a multicenter North American prospective cohort study. Spine 2013; 38(2):97-103.
  66. Wilson JR, BSc LT, Aarabi B, Anderson PA, Arnold PM, Brodke DS et al. Guidelines for the management of patients with spinal cord injury: the optimal timing of decompression. Neurosurgery 2016; 63 Suppl 1:172.
  67. Wimberley DW, Vaccaro AR, Goyal N, Harrop JS, Anderson DG, Albert TJ et al. Acute quadriplegia following closed traction reduction of a cervical facet dislocation in the setting of ossification of the posterior longitudinal ligament: case report. Spine 2005; 30(15):E433-E438.
  68. Yadla S, Lebude B, Tender GC, Sharan AD, Harrop JS, Hilibrand AS et al. Traumatic spondyloptosis of the thoracolumbar spine. J Neurosurg Spine 2008; 9(2):145-151.
  69. Yadla S, Klimo P, Jr., Harrop JS. Traumatic central cord syndrome: etiology, management, and outcomes. Top Spinal Cord Inj Rehabil 2010; 15(3):73-84.
  70. Zohrabian VM, Parker L, Harrop JS, Vaccaro AR, Marino RJ, Flanders AE. Can anatomic level of injury on MRI predict neurological level in acute cervical spinal cord injury? Br J Neurosurg 2016; 30(2):204-210.
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